Nuclear Size Is Regulated by Importin α and Ntf2 in Xenopus
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چکیده
منابع مشابه
Nuclear Size Is Regulated by Importin α and Ntf2 in Xenopus
The size of the nucleus varies among different cell types, species, and disease states, but mechanisms of nuclear size regulation are poorly understood. We investigated nuclear scaling in the pseudotetraploid frog Xenopus laevis and its smaller diploid relative Xenopus tropicalis, which contains smaller cells and nuclei. Nuclear scaling was recapitulated in vitro using egg extracts, demonstrati...
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Importin α is recognized as a classical nuclear localization signal (cNLS) receptor which mediates nucleocytoplasmic transport. However, it rapidly accumulates in the nucleus in response to cellular stresses, including oxidative stress, causing a blockade of the classical nuclear import pathway. We set out to determine whether importin α performs roles in the nucleus after cellular exposure to ...
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Histone acetylases were originally identified because of their ability to acetylate histone substrates [1–3]. Acetylases can also target other proteins such as transcription factors [4–7]. We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription. A large panel of proteins, involved in a variety of cellular processes, were tested a...
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Myocardin-related transcription factors (MRTFs) are actin-regulated transcriptional coactivators, which bind G-actin through their N-terminal RPEL domains. In response to signal-induced actin polymerisation and concomitant G-actin depletion, MRTFs accumulate in the nucleus and activate target gene transcription through their partner protein SRF. Nuclear accumulation of MRTFs in response to sign...
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1996) and the KNS shuttling domain of the hnRNP K * Zentrum fü r Molekulare Biologie der protein, which allows both import and export (Michael Universitä t Heidelberg et al., 1997). 69120 Heidelberg A fundamental question is how it is possible for the Federal Republic of Germany shuttling transport receptors to carry their cargo in only † Abteilung Molekulare Biologie der Mitose one direction. ...
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ژورنال
عنوان ژورنال: Cell
سال: 2010
ISSN: 0092-8674
DOI: 10.1016/j.cell.2010.09.012